Effects of Environmental pH on the Growth of Gastric Cancer Cells

Figure 1

Alkaline microenvironment inhibited the viability of GC cells. Compared with the blank control group, the optical density (OD) value increased in the pH 6.0 or pH 7.0 group, and the inhibition rate was negative, indicating cell promotion. When the OD value of the pH 8.0 group was lower than that of the blank group, the inhibition rate was positive, indicating cells inhibition. When pH 6.0 or pH 7.0, the viability of GC cells was promoted. The smaller the pH value was, the smaller the inhibition rate of cells was, and the greater the viability of cells was. However, in the pH 8.0 group, the viability of GC cells was inhibited, showing that the alkaline environment inhibited the viability of GC cells (b). (a) Viability analysis of GC cells (SGC-7901 and MKN45) treated with different culture times (12 h, 24 h, and 48 h). (b) Viability analysis of GC cells (SGC-7901 and MKN45) treated with culture media of different pH values (pH 6.0, pH 7.0, and pH 8.0).

(a)

(b)