Clinicopathologic Characteristics and Long-Term Outcome of Gastric Cancer Patients with Family History: Seven-Year Follow-Up Study for Korean Health Check-Up Subjects
Table 2
Clinicopathologic findings of gastric cancer patients.
Family history of gastric cancer
value
Absent ()
Present ()
No.
%
No.
%
Tumor location
0.17
Upper third
29
11.6
8
12.3
Middle third
79
31.5
13
20
Lower third
139
55.4
41
63.1
All
4
1.6
3
4.6
Tumor size (cm)
0.78
<1.0
46
18.3
11
16.9
1.0-1.9
73
29.1
19
29.2
2.0-2.9
41
16.3
14
21.5
≥3.0
91
36.3
21
32.3
0.991
Differentiation
0.197
Differentiated
132
52.6
40
61.5
Undifferentiated
119
47.4
25
38.5
Laruen classification
0.491
Intestinal
133
57.1
39
61.9
Diffuse or mixed
100
42.9
24
38.1
Depth of invasion
0.756
pT1
193
76.9
49
75.4
pT2
32
12.7
11
16.9
pT3
13
5.2
3
4.6
pT4
13
5.2
2
3.1
Lymph node metastasis
0.235
pN0
199
79.3
56
86.2
pN1
26
10.4
6
9.2
pN2
15
6
0
0
pN3
11
4.4
3
4.6
Multiplicity of tumor
0.653
Solitary
239
95.2
61
93.8
Multiple
12
4.8
4
6.2
Stage
0.698
I
204
81.3
56
86.2
II
28
11.2
4
6.2
III
8
3.2
2
3.1
IV
11
4.4
3
4.6
Preexisting adenoma
0.035
Yes
15
6.3
9
14.5
No
222
93.7
53
85.5
Microsatellite instability
0.006
Stable
86
86.8
21
56.8
Unstable, low (MSI-L)
6
6.1
7
18.9
Unstable, high (MSI-H)
7
7.1
9
24.3
Curative treatment method
0.538
ESD
78
32.6
18
28.6
Surgery (STG+TG)
161
67.4
45
71.4
H. pylori infection status
0.188
Yes
138
61.3
43
70.5
No
87
38.7
18
29.5
Atrophic gastritis
0.354
Yes
231
92
62
95.4
No
20
8
3
4.6
Intestinal metaplasia
0.113
Yes
137
53.8
44
67.7
No
114
45.4
21
32.3
ESD: endoscopic submucosal dissection; H. pylori: Helicobacter pylori; SD: standard deviation; STG: subtotal gastrectomy; TG: total gastrectomy. Microsatellite instability was evaluated in 136 of the patients (43% of total study population) who underwent ESD or surgery.
