Interplay of PNPLA3 and HSD17B13 Variants in Modulating the Risk of Hepatocellular Carcinoma among Hepatitis C Patients

Table 3

Conditional logistic regression model of predictors of hepatocellular carcinoma. High-risk genetic combination defined as being at the same time the carrier of the variant rs738409 G allele and of the major allele rs72613567 allele.

Covariate		Odds ratio	95% confidence interval	value
High-risk genetic combination
No	331	(Ref.)	(Ref.)	(Ref.)
Yes	109	1.96	1.19-3.21	0.008
History of alcohol abuse
No	376	(Ref.)	(Ref.)	(Ref.)
Yes	64	2.47	1.32-4.64	0.005
Diabetes mellitus
No	359	(Ref.)	(Ref.)	(Ref.)
Yes	81	1.66	0.96-2.88	0.067
No	226	(Ref.)	(Ref.)	(Ref.)
Yes	214	2.41	1.53-3.81	<0.001

Abbreviations: APRI: AST to platelet ratio index; Ref. = reference.