Effect of the Type of Intraoperative Restrictive Fluid Management on the Outcome of Pancreaticoduodenectomy: A Systematic Review and Meta-Analysis

Table 1

Baseline characteristics of included studies.

Author	Published year	Study type	Age (mean)	ASA ≥ III (%)	Surgical procedure	Restrictive fluid	Liberal fluid	Restrictive group ()	Liberal group ()	Total ()	Mortality
Michal Barak [7]	2006	Prospective study	61	63	PD	Balance 0 to +1000 ml	Balance +1000 to +2000 ml	14	18	32	30-day mortality
Mary Fischer [17]	2010	Prospective study	64.5	28	PD	3900 ml	6250 ml	65	65	130	90-day mortality
Marcovalerio Melis [9]	2011	Retrospective analysis	66.4	49	PD	<6000 ml	>6000 ml	86	102	188	30-day mortality
Oliver S. Eng [18]	2013	Retrospective analysis	64.5	NR	PD	<13.5 ml/kg/hr	>13.5 ml/kg/hr	62	62	124	30-day mortality
Sizhen Wang [19]	2014	Retrospective analysis	53.5	35	PD	<8.2 ml/kg/hr	>8.2 ml/kg/hr	90	57	147	In-hospital
Ganapathy van Samkar [20]	2015	Prospective study	NR	4	P	5 ml/kg/hr	10 ml/kg/hr	34	32	66	In-hospital, 6-year mortality
Florence Grant [10]	2016	Prospective study	65	42	P	6 mL/kg/h	12 mL/kg/h	166	164	330	In-hospital, 60-day mortality
Mark A. Healy [8]	2016	Retrospective analysis	67.1	77	P	<10 ml/kg/h	>15 ml/kg/h	167	152	319	30-day mortality
Birte Kulemann [21]	2017	Retrospective analysis	66	35	PD	<6000 ml	>6000 ml	304	249	553	In-hospital
In Woong Han [22]	2017	Retrospective analysis	62	NR	PD	Actual IOF < planned IOF	Actual IOF ≥ planned IOF	84	98	182	30-day mortality
Laurence Weinberg [23]	2017	Retrospective analysis	66	33	P	4.7 ml/kg/h	7.8 ml/kg/h	47	98	145	30-day mortality
Laurence Weinberg [24]	2017	Prospective study	65	73	PD	2050 ml	4088 ml	26	26	52	NR
Preetjote Gill [25]	2017	Retrospective analysis	64	28	PD	<10 mL/kg/h	>10 mL/kg/h	76	126	202	30-day mortality
Stefano Andrianello [26]	2018	Prospective study	65	30	PD	2500 ml	3700 ml	63	63	126	In-hospital

PD: pancreaticoduodenectomy; P: all pancreatectomy included; NR: not reported; IOF: intraoperative fluid.