Predictive and Prognostic Factors of Synchronous Colorectal Lung-Limited Metastasis

Table 3

Univariable and multivariable Cox regression model.

Characteristics	Univariable analysis				Multivariable analysis
	OR	95% CI lower	95% CI upper	value	OR	95% CI lower	95% CI upper	value
Gender				0.609
Female		Reference				NA
Male	1.039	0.898	1.203	0.609
Age (years)				<0.001				<0.001
<65		Reference				Reference
65-74	1.318	1.089	1.594	0.004	1.278	1.050	1.557	0.014
≥75	2.531	2.136	3.000	<0.001	2.014	1.663	2.440	<0.001
Marital status				<0.001				0.003
Married		Reference				Reference
Unmarried/NOS	1.427	1.231	1.654	<0.001	1.263	1.082	1.475	0.003
Insurance
Yes		Reference				NA
No/unknown	1.126	0.830	1.527	0.447
Race				0.040				0.035
White		Reference				Reference
Black	0.866	0.700	1.071	0.185	0.950	0.760	1.188	0.653
Other/NOS	0.730	0.558	0.954	0.021	0.695	0.528	0.916	0.010
Tumor location				0.008				0.465
Right colon		Reference				Reference
Left colon	0.742	0.600	0.916	0.006	0.930	0.746	1.158	0.515
Rectum	0.788	0.663	0.936	0.007	0.840	0.677	1.043	0.114
NOS	1.246	0.696	2.232	0.459	0.988	0.538	1.812	0.968
Pathological grade				<0.001				<0.001
I/II		Reference				Reference
III/IV	1.426	1.172	1.734	<0.001	1.526	1.241	1.878	<0.001
Unknown	1.475	1.204	1.807	<0.001	1.011	0.808	1.266	0.920
Histological type				0.214
Adenocarcinomas		Reference				NA
MCC/SRCC	1.204	0.898	1.614	0.214
T stage				<0.001				<0.001
Tis-2		Reference				Reference
T3	0.746	0.612	0.909	0.004	1.268	1.000	1.607	0.050
T4	1.172	0.943	1.456	0.154	1.962	1.511	2.548	<0.001
N stage				0.036				0.169
N0		Reference				Reference
N1	0.804	0.681	0.949	0.010	0.958	0.796	1.154	0.653
N2	0.901	0.743	1.092	0.287	1.168	0.925	1.476	0.193
Colectomy/proctectomy				<0.001				<0.001
Standard resection		Reference				Reference
Simplified resection	1.294	1.041	1.608	0.020	1.434	1.138	1.805	0.002
Nonresection/NOS	1.914	1.631	2.246	<0.001	2.895	2.078	4.034	<0.001
Pulmonary surgery				<0.001				0.246
Yes		Reference				Reference
No/unknown	2.061	1.512	2.808	<0.001	1.208	0.878	1.663	0.246
Radiotherapy				0.003				0.124
Yes		Reference				Reference
No/unknown	1.289	1.090	1.523	0.003	1.172	.957	1.436	0.124
Chemotherapy				<0.001				<0.001
Yes		Reference				Reference
No/unknown	2.694	2.314	3.137	<0.001	2.179	1.830	2.594	<0.001
Tumor size				<0.001				0.220
≤5 cm		Reference				Reference
5-10 cm	1.144	0.966	1.355	0.119	1.069	0.898	1.272	0.454
>10 cm	2.040	1.466	2.838	<0.001	1.436	1.016	2.030	0.040
NOS	1.453	1.186	1.780	<0.001	1.104	0.877	1.390	0.401
CEA				0.004				0.006
Normal		Reference				Reference
Elevated	1.376	1.129	1.675	0.002	1.381	1.128	1.692	0.002
NOS	1.362	1.106	1.676	0.004	1.182	.952	1.468	0.131
TD				<0.001				0.001
Negative		Reference				Reference
Positive	1.493	1.216	1.832	<0.001	1.494	1.194	1.868	<0.001
NOS	1.807	1.535	2.128	<0.001	.908	.673	1.224	0.525
PNI				<0.001				0.404
Negative		Reference				Reference
Positive	1.188	0.967	1.459	0.101	1.162	0.923	1.462	0.201
NOS	1.524	1.291	1.798	<0.001	1.060	0.867	1.297	0.569

MCC: mucinous cell carcinoma; SRCC: signet ring cell carcinoma; CEA: carcinoembryonic antigen; TD: tumor deposits; PNI: perineural invasion; NOS: not otherwise specified; NA: unavailable.