miR-21 Overexpression Promotes Esophageal Squamous Cell Carcinoma Invasion and Migration by Repressing Tropomyosin 1

Figure 4

miR-21 promotes ESCC migration and invasion via inhibiting TPM1. (a–c) The effect of cotransfection with miR-21 inhibitors and TPM1 inhibitors was verified by RT-PCR and WB in EC109 and K30 cell lines. (d, e) Invasion and migration of EC109 and K30 cells were evaluated by the transwell assay, showing that invasion and migration were maintained after double silencing of miR-21 and TPM1.

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