Patients’ Educational Program Could Improve Azathioprine Adherence in Crohn’s Disease Maintenance Therapy

Table 1

Univariate analysis of risk factors for nonadherence in AZA maintenance.

Features	Adherence ()	Nonadherence ()	value
Male sex	130 (61.3)	89 (53.6)	0.132
Age			0.034
Married	108 (50.9)	71 (42.8)	0.114
Offspring	92 (43.4)	72 (43.4)	0.996
Education			<0.001
Primary school	10 (4.7)	5 (3.0)
Secondary school	31 (14.6)	10 (6.0)
High school	73 (34.4)	40 (24.1)
College	93 (43.9)	90 (54.2)
Postgraduate	5 (2.4)	21 (12.7)
Family income per month			0.614
>10 thousand USD	20 (9.4)	17 (10.2)
5-10 thousand USD	30 (14.2)	21 (12.7)
2-5 thousand USD	58 (27.4)	49 (29.5)
1-2 thousand USD	79 (37.3)	52 (31.3)
<1 thousand USD	25 (11.8)	27 (16.3)
Cost of disease per year			0.328
>10 thousand USD	51 (24.1)	34 (20.5)
5-10 thousand USD	81 (38.2)	76 (45.8)
<5 thousand USD	80 (37.7)	56 (33.7)
Smoking	8 (3.8)	13 (7.8)	0.087
Alcoholism	4 (1.9)	11 (6.6)	0.019
Disease duration (yrs)			0.749
Age of onset			0.509
<17 years old (A1)	18 (8.5)	19 (11.4)
17-40 years old (A2)	177 (83.5)	131 (78.9)
>40 years old (A3)	17 (8.0)	16 (9.7)
Location of lesions			0.201
Ileum (L1)	89 (41.9)	85 (51.2)
Colon (L2)	30 (14.2)	19 (11.4)
Ileocolon (L3)	93 (43.9)	62 (37.3)
Behavior			0.422
Nonstricture nonpenetrating	144 (67.9)	102 (61.4)
Stricture	44 (20.8)	41 (24.7)
Penetrating	24 (11.3)	23 (13.9)
Perianal disease	69 (32.5)	49 (29.5)	0.528
CD-related surgery	42 (19.8)	39 (23.5)	0.387
Anxiety			<0.001
Depression			<0.001
AZA usage
Dosage (mg/d)			0.082
Duration (months)			0.157
Necessity belief			<0.001
Concerns belief			<0.001
Knowledge			0.028
Side effect	28 (13.2)	19 (11.4)	0.606