Prognostic Value of the Pretreatment Systemic Immune-Inflammation Index in Patients with Colorectal Cancer

Table 3

Associations between SII and clinicopathological parameters.

Variable	No. of studies	No. of patients	Effects model	OR (95% CI)		Heterogeneity
						ECOG performance status (0 vs. 1-2)	3	607	Fixed	1.212 (1.097-1.340)	<0.001	0.00%	0.732
Tumor location (colon vs. rectum)	5	884	Fixed	0.928 (0.839-1.027)	0.149	40.80%	0.15
Tumor differentiation (moderate/high vs. poor)	6	2096	Random	1.058 (0.953-1.175)	0.291	64.90%	0.014
T (0-2 vs. 3)	3	1663	Fixed	1.651 (1.380-1.976)	<0.001	32.10%	0.229
Chemotherapy (no vs. yes)	3	486	Fixed	1.139 (0.962-1.350)	0.132	2.70%	0.358

ECOG: Eastern Cooperative Oncology Group; SII: systemic immune-inflammation index; OR: odds ratio; CI: confidence interval.