p53 Immunohistochemistry Patterns Are Surrogate Biomarkers for TP53 Mutations in Gastrointestinal Neuroendocrine Neoplasms

Table 1

Clinicopathological characteristics of 92 GI-NENs.

Clinicopathological features	NET no. (%)	NEC no. (%)
Sex
Male	18 (51.4)	39 (68.4)
Female	17 (48.6)	18 (31.6)
Age at diagnosis
Median	53	66
Mean	50.9	65.0
Range	32-72	47-86
Tumor location
Esophagus	1 (2.9)	6 (10.5)
Stomach	12 (34.2)	38 (66.7)
Small intestine	3 (8.6)	4 (7.0)
Colorectum	19 (54.3)	9 (15.8)
TNM stage
I-II	26 (74.3)	30 (52.6)
III	5 (14.3)	18 (31.6)
IV	4 (11.4)	9 (15.8)
Regional/distant metastasis
Positive	5 (14.3)	38 (66.7)
Negative	30 (85.7)	19 (33.3)