Immune Modulation Effects of Lactobacillus casei Variety rhamnosus on Enterocytes and Intestinal Stem Cells in a 5-FU-Induced Mucositis Mouse Model

Figure 2

Diarrhea score change in saline- or 5-FU-injected mice with/without probiotic Lcr35 administration. The mice were recorded daily, and the results of all groups were compared with those in the 5-FU+saline group for 5 days. In the control groups, the mice were injected with saline and administrated with saline or Lcr35. In the experimental groups, the mice were injected with 5-FU and administrated with or without Lcr35. Diarrhea scores increased from the 1^st day after 5-FU treatment. Diarrhea scores of the 5-FU+Lcr35 group () significantly decreased when compared to those of the 5-FU group () (). The severity of diarrhea was attenuated after probiotic administration in the 5-FU+Lcr35 group. Statistical analysis was performed by one-way ANOVA.