Factors Associated with Mortality in Severe Acute Cholangitis in a Moroccan Intensive Care Unit: A Retrospective Analysis of 140 Cases
Table 1
TG18/TG13 diagnostic criteria for acute cholangitis. Adapted from Kiriyama et al. [24].
(A) Systemic inflammation (A-1) Fever () and/or shaking chills (A-2) Evidence of Inflammatory Response. White blood cells (WBC) or >10000/mm3, C-reactive .
(B) Cholestasis (B-1) Jaundice. Total . (B-2) Abnormal Liver Function Tests. AST, ALT, ALP, r-GTP ().
(C) Imaging (C-1) Biliary dilatation (C-2) Evidence of etiology on imaging (stricture, stone, stent, etc.)
Suspected diagnosis: one item in A + one item in either B or C. Definite diagnosis: One item in A + one item in B + one item in C.
Other factors may be helpful in diagnosis of acute cholangitis: right upper quadrant or upper abdominal pain, a history of biliary disease (gallstones, previous biliary procedures, biliary stent). In acute hepatitis, marked systematic inflammatory response is observed infrequently. Virological and serological tests are required when differential diagnosis is difficult.
ALP: alkaline phosphatase; r-GTP (GGT): r-glutamyltransferase; AST: aspartate aminotransferase; ALT: alanine aminotransferase; STD: upper limit of normal value.
