Factors Associated with Mortality in Severe Acute Cholangitis in a Moroccan Intensive Care Unit: A Retrospective Analysis of 140 Cases
Table 2
Severity assessment of acute cholangitis.
(a)
TG 18/TG13 severity assessment criteria for acute cholangitis. Adapted from Kiriyama et al. [24]
Grade III (severe): acute cholangitis + one dysfunction at least in any of the following systems: (i) Cardiovascular. Hypotension requiring vasopressors. (ii) Neurological. Disturbance of consciousness. (iii) Respiratory. PaO2/FiO2 (arterial oxygen partial pressure to fractional inspired oxygen ratio). (iv) Renal. Oliguria, . (v) Hepatic. PT– (prothrombin-international normalized ratio). (vi) Hematologic. Platelet . Grade II (moderate): acute cholangitis + any two of the following conditions: (i) Abnormal WBC count (>12000/mm3 or < 4000/mm3) (ii) (iii) (iv) Hyperbilirubinemia (total ) (v) Hypoalbuminemia () Grade I (mild): acute cholangitis does not meet the criteria of “Grade III (severe)” or “Grade II (moderate)” acute cholangitis at initial diagnosis.
(b)
Sequential Organ Failure Assessment (SOFA) score [25]. Based on the degree of dysfunction of 6 organ systems: respiratory, hematologic, hepatic, cardiovascular, neurological, and renal.
Variables/score
0
1
2
3
4
PaO2/FiO2 (mmHg)
> 400
≤ 400
≤ 300
≤ 200
≤ 100
Platelets (×103/mm3)
> 150
≤ 150
≤ 100
≤ 50
≤ 20
Bilirubin (mg/l)
< 12
12-19
20-59
60-119
> 120
Cardiovascular (μg/kg/min)
No hypotension
or Dobu (any dose)
or
or
Glasgow coma scale
15
13-14
10-12
6-9
< 6
Creatinine (mg/l) or urine output
< 12
12-19
20-34
35–49 or < 500 ml/day
> 50 or < 200 ml/day
MAP: mean arterial pressure; Dopa: dopamine; Dobu: dobutamine; Norepi: norepinephrine.
