Research Article

Factors Associated with Mortality in Severe Acute Cholangitis in a Moroccan Intensive Care Unit: A Retrospective Analysis of 140 Cases

Table 3

Univariate analysis of risk factors for mortality in severe acute cholangitis.

FactorsSurvivors ()Nonsurvivors ()valueBrut OR (95% CI)

Age, 0.150
, (%)27 (26.7%)10 (25.6%)0.8960.94 (0.40-2.19)
Female gender, (%)67 (66.3%)21 (53.8%)0.170
Comorbidities, (%)
 Diabetes15 (14.85%)7 (17.94%)0.414
 Cancer3 (2.97%)1 (2.56%)0.690
 Heart disease22 (21.78%)11 (28.2%)0.277
 Stroke6 (5.9%)2 (5.1%)0.8530.85 (0.16-4.43)
 Antithrombotic therapy5 (5%)10 (25.6%)≤0.0016.62 (2.09-20.93)
 History of complicated lithiasic disease9 (8.9%)2 (5.1%)0.4560.55 (0.11-2.68)
 History of biliary procedure41 (40.6%)14 (35.9%)0.6100.82 (0.38-1.76)
Time to hospital consultation (days), 12.03 ± 5.4260.003
Type of admission, (%)
 Emergency85 (84.2%)27 (69.23%)0.0480.42 (0.17-1.00)
 Surgical ward15 (14.9%)7 (17.9%)0.6521.25 (0.46-3.35)
 Medical ward1 (1%)5 (12.82%)0.00214.70 (1.65-130.3)
Charcot triad, (%)94 (96.03%)36 (92.3%)0.563
Etiology, (%)
 Lithiasic75 (74.3%)22 (56.4%)0.0400.44 (0.20-0.97)
 Tumor10 (9.9%)11 (28.2%)0.007
 Hydatic12 (11.9%)6 (15.4%)0.5791.34 (0.46-3.88)
Severity assessment upon admission
 Septic shock, (%)7 (6.9%)25 (64.1%)≤0.001
 Respiratory failure, (%)11 (10.89%)15 (38.5%)≤0.001
 GCS, 14.5213.07≤0.001
 GCS< 15, (%)22 (21.8%)25 (64.21%)≤0.0016.41 (2.86-14.37)
 Quick-, (%)24 (23.76%)27 (69.2%)≤0.001
 SOFA, ≤0.001
 TOKYO Grade III, (%)76 (75.2%)38 (97.4%)0.002
Laboratory finding upon admission,
 Creatinine, mg/l23.2037.180.001
 White blood cell count, /mm319718.423888.50.257
 C-reactive protein, mg/l197.5209.840.496
 Aspartate amino transferase, IU/l166.91208.250.185
 Alanine aminotransferase, IU/l141.81202.580.139
 Alkaline phosphatase, IU/l364.924780.052
 Total bilirubin, mg/l106.5174.760.002
 Prothrombin , (%)33 (32.7%)16 (41.02%)0.353
Organ support therapies
 Catecholamines, (%)21 (20.8%)32 (82.1%)≤0.00117.41 (6.74-44.96)
 Mechanical ventilation, (%)6 (5.9%)26 (66.7%)≤0.00131.66 (10.96-91.41)
 Dialysis, (%)2 (2%)7 (17.9%)0.00110.82 (2.14-54.78)
Initial empiric antibiotherapy, (%)
 Amoxicillin + clavulanic acid13 (12.9%)4 (10.3%)0.6710.77 (2.36-2.53)
 Ceftriaxone + metronidazole87 (86.1%)35 (89.7%)0.5681.40 (0.43-4.57)
Time to biliary decompression (days), 0.910
Decompression technique, (%)
 Endoscopic82 (81.2%)29 (74.4%)0.3710.67 (0.28-1.61)
 Surgical16 (15.8%)6 (15.4%)0.9470.96 (0.34-2.68)
 Percutaneous2 (2%)1 (2.6%)0.8311.30 (0.11-14.78)
Persistence of renal failure after decompression, (%)3 (3%)10 (25.6%)≤0.00111.26 (2.90-43.67)
Persistence of hematological failure after decompression, (%)5 (5%)35 (89.7%)≤0.001168 (42.66-661.50)
ICU stay (days), 0.988
Septic shock during ICU stay, (%)0 (0%)35 (89.7%)≤0.001