Prognostic Value of Inflammatory and Tumour Markers in Small-Duct Subtype Intrahepatic Cholangiocarcinoma after Curative-Intent Resection

Table 2

Multivariate analysis of prognostic factors for ICC in the training cohort.

Variables	DFS			OS
	HR	95% CI	value	HR	95% CI	value
Inflammatory factors
Neutrophil (10^9/L)	1.791	1.063-3.017	0.029	2.098	1.095-4.019	0.025
(<4.15 vs. ≥4.15)
Lymphocyte (10^9/L)	0.594	0.332-1.061	0.078
(<1.60 vs. ≥1.60)
Monocyte (10^9/L)				2.042	0.884-4.714	0.095
(<0.54 vs. ≥0.54)
NLR	1.554	0.801-3.013	0.192	2.117	0.944-4.748	0.069
(<3.00 vs. ≥3.00)
LMR	0.772	0.339-1.758	0.537	0.367	0.136-0.993	0.048
(<2.70 vs. ≥2.70)
PII	1.904	1.017-3.563	0.044	3.360	1.604-7.038	0.001
(<1.50 vs. ≥1.50)
Tumour markers
CEA (ug/L)	2.414	1.383-4.214	0.002	1.851	0.856-4.001	0.118
(<4.50 vs. ≥4.50)
CA19-9 (U/ml)	2.934	1.696-5.074	≤0.001	3.358	1.668-6.760	0.001
(<76.0 vs. ≥76.0)
CA242 (IU/ml)	2.737	1.488-5.036	0.001	2.348	1.103-5.001	0.027
(<30.0 vs. ≥30.0)
Ferritin (ug/L)	2.534	1.352-4.750	0.004	3.779	1.590-9.077	0.003
(<150.0 vs. ≥150.0)