Prognostic Value of Inflammatory and Tumour Markers in Small-Duct Subtype Intrahepatic Cholangiocarcinoma after Curative-Intent Resection

Table 4

Multivariate analysis of prognostic factors for small-duct type ICC in the training cohort.

Variables	DFS			OS
	HR	95% CI	value	HR	95% CI	value
Inflammatory factors
Neutrophil (10^9/L)	1.498	0.801-2.801	0.206
(<4.15 vs. ≥4.15)
Lymphocyte (10^9/L)	0.450	0.232-0.870	0.018	0.495	0.217-1.131	0.095
(<1.60 vs. ≥1.60)
NLR				1.666	0.543-5.110	0.372
(<3.00 vs. ≥3.00)
LMR				0.250	0.071-0.882	0.031
(<2.70 vs. ≥2.70)
PII	1.674	0.792-3.540	0.177	3.215	1.350-7.655	0.008
(<1.50 vs. ≥1.50)
Tumour markers
CEA (ug/L)	2.583	1.251-5.334	0.010
(<4.50 vs. ≥4.50)
CA19-9 (U/ml)	2.946	1.442-6.020	0.003	3.792	1.542-9.327	0.004
(<76.0 vs. ≥76.0)
CA242 (IU/ml)	2.988	1.287-6.938	0.011
(<30.0 vs. ≥30.0)
Ferritin (ug/L)	2.052	0.987-4.265	0.054	2.903	1.037-8.127	0.042
(<150.0 vs. ≥150.0)