Extrapolating Prognostic Factors of Primary Curative Resection to Postresection Recurrences Hepatocellular Carcinoma Treatable by Radiofrequency Ablation

Table 1

Univariate analysis of the prognostic factors contributing to OS and RFS of recurrent HCC patients undergoing RFA.

	Variables	n	OS; value^1	RFS; value^1
Factors of primary curative resection	Gender, male/female	196/39	0.443	0.111
	Age (>55years), yes/no	120/115	0.581	0.769
	Hepatitis, yes/no	214/21	0.306	0.321
Factors of primary curative resection	Tumor size (>3 cm), yes/no	127/108	0.652	0.592
	Tumor number, multiple/single	51/184	0.729	0.319
	Tumor differentiation (>II), yes/no	64/171	0.032	0.048
	Microvascular invasion, yes/no	56/179	0.380	0.289
	Encapsulation invasion, yes/no	7/228	0.672	0.216
	Star lesion, yes/no	6/229	0.650	0.051
	Postoperative adjuvant TACE, yes/no	69/166	0.050	0.101
	Time to recurrence after curative resection (≤9 months), yes/no	78/157	0.006	<0.001
Features before RFA	TB (>17.1 μmol/l), yes/no	30/205	0.129	0.084
	ALT (>50 IU/l), yes/no	32/203	0.375	0.718
	PT (>14 s), yes/no	14/221	0.066	0.979
	Albumin (≤3.5 g/dl), yes/no	12/223	0.781	0.361
	GGT (>50 IU/l), yes/no	95/140	0.002	0.022
	AFP (>20 ng/ml), yes/no	80/155	0.010	0.292
	Tumor size (>2.0 cm), yes/no	72/163	0.830	0.853
	Tumor number, multiple/single	36/199	0.622	0.023

OS: overall survival; RFS: recurrence-free survival; RFA: radiofrequency ablation; TB: total bilirubin; ALT: alanine aminotransferase; PT: prothrombin time; GGT: γ-glutamyltranspeptidase; AFP: alpha-fetoprotein; ¹log-rank test.