Predictors of Long-Time Survivors in Nonmetastatic Colorectal Signet Ring Cell Carcinoma: A Large Population-Based Study

Table 2

Logistic regression analysis to identify predictors of long-time survivors in nonmetastatic colorectal SRCC^† in the training cohort.

Variables	Unadjusted logistic regression		Adjusted logistic regression
	OR^‡ (95% CI^§)		OR (95% CI)
Age
≤40	Reference		Reference
41-55	1.69 (1.07-2.72)	0.028	1.29 (0.79-2.16)	0.320
56-70	1.35 (0.87-2.14)	0.186	0.79 (0.49-1.30)	0.338
>70	1.22 (0.79-1.91)	0.382	0.69 (0.42-1.15)	0.146
Race
Black	Reference		Reference
White	2.29 (1.47-3.69)	<0.001	2.57 (1.60-4.30)	<0.001
Other	1.37 (0.75-2.50)	0.305	1.84 (0.97-3.54)	0.064
Unknown	1.51 (0.07-12.41)	0.724	1.76 (0.08-15.05)	0.634
Sex
Male	Reference
Female	1.18 (0.95-1.47)	0.14
Marital status
Unmarried	Reference		Reference
Married	1.42 (1.13-1.79)	0.003	1.34 (1.04-1.73)	0.023
Unknown	0.80 (0.42-1.43)	0.475	0.66 (0.33-1.25)	0.220
Tumor grade
Well/moderately	Reference		Reference
Poorly/undifferentiated	0.54 (0.36-0.80)	0.002	0.73 (0.48-1.12)	0.149
Unknown	0.80 (0.49-1.32)	0.380	0.98 (0.56-1.72)	0.951
Tumor size (cm)
≤ 4	Reference
4.1-6	0.79 (0.59-1.06)	0.117
>6	0.79 (0.60-1.04)	0.099
Unknown	0.74 (0.50-1.08)	0.126
Tumor location
Right colon	Reference		Reference
Left colon	0.97 (0.70-1.32)	0.840	1.04 (0.72-1.47)	0.848
Rectum	0.69 (0.51-0.92)	0.012	0.91 (0.53-1.53)	0.719
Unknown	0.96 (0.39-2.19)	0.931	1.44 (0.56-3.44)	0.429
Number of lymph node examined
< 12	Reference
≥ 12	1.08 (0.84-1.39)	0.545
Unknown	0.67 (0.19-1.90)	0.483
T stage
T4	Reference		Reference
T3	2.43 (1.85-3.22)	<0.001	2.13 (1.59-2.88)	<0.001
T2	3.51 (2.15-5.70)	<0.001	2.42 (1.43-4.11)	0.001
Tis-T1	4.43 (2.79-7.06)	<0.001	3.64 (2.07-6.45)	<0.001
N stage
N2	Reference		Reference
N1	1.91 (1.41-2.59)	<0.001	2.07 (1.50-2.87)	<0.001
N0	3.35 (2.57-4.38)	<0.001	2.87 (2.09-3.96)	<0.001
Primary tumor treatment
No	Reference		Reference
Surgery	14.44 (4.49-88.28)	<0.001	21.38 (6.28-134.38)	<0.001
Local tumor excision	30.50 (6.63-223.18)	<0.001	22.80 (4.68-172.76)	<0.001
Radiation
No/unknown	Reference		Reference
Yes	0.64 (0.46-0.87)	0.006	0.70 (0.39-1.25)	0.234
Chemotherapy
No/unknown	Reference		Reference
Yes	0.70 (0.56-0.88)	0.002	1.00 (0.74-1.35)	0.984

^†SRCC: signet ring cell carcinoma; ^‡OR: odds ratio; ^§CI: confidence interval.