Downregulation of LncRNA SNHG7 Sensitizes Colorectal Cancer Cells to Resist Anlotinib by Regulating miR-181a-5p/GATA6

<div>The expression of SNHG7 is upregulated in CRC. (a) Gene expression profiling interactive analysis (GEPIA) of the TCGA data to assess SNHG7 expression in rectal cancer (red column). (b) SNHG7 expression in the GEO dataset GSE75970. (c) qRT-PCR measurement to check the expression level of SNHG7 in 50 pairs of CRCs and the paracancerous tissues. (d) qRT-PCR analysis to determine the expression level of SNHG7 in CRC cell lines, HT29, HCT116, HCT8, LOVO, SW480, SW620, and DLD1 as well as in the normal cell line NCM460. (e) qRT-PCR analysis to detect SNHG7 expression in ATB-resistant cell lines HCT116/ATB and LOVO/ATB. 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Gastroenterology Research and Practice

fig1

Figure 1

Figure 1: Downregulation of LncRNA SNHG7 Sensitizes Colorectal Cancer Cells to Resist Anlotinib by Regulating miR-181a-5p/GATA6 