Comparison of Gastric Cancer Risk Classifications Using Conventional and New Pepsinogen Criteria

Table 2

Comparison of gastric cancer risk classification results between the conventional and new PG criteria in combination with H. pylori antibody.

Cutoff value for serum H. pylori antibody = 2.3 EV			Patients with GC					Controls
			New PG criteria that are indicative of H. pylori infection					New PG criteria that are indicative of H. pylori infection
			PG II ≥ 10 ng/mL or PG I/PG II ≤ 5					PG II ≥ 10 ng/mL or PG I/PG II ≤ 5
			Low risk		High risk^†			Low risk		High risk^†
			n	95% CI^‡	n	95% CI^‡		n	95% CI^‡	n	95% CI^‡
							Total (GC risk classification)					Total (GC risk classification)
GC risk classification	Low risk		2	(0, 5)	6	(2, 11)	8	66	(53, 80)	23	(14, 32)	89
PG I ≤ 70 ng/mL and PG I/PG II ≤ 3	High risk^†		0	(0, 0)	267	(261, 272)	267	0	(0, 0)	186	(171, 201)	186
		Total (new PG criteria)	2		273			66		209

^†If serum H. pylori antibody titer was ≥2.3 EV, it was defined as antibody-positive. If the PG values satisfied the criteria, it was defined as PG-positive. When both antibody and PG were negative, it was defined as low risk. In all other cases, it was defined as high risk.
^‡Bootstrapped 95% confidence intervals from 10,000 re-samplings when the new PG cutoff values were applied.
PG, pepsinogen; H. pylori, Helicobacter pylori; EV, enzyme-linked immunosorbent assay value; CI, confidence interval; GC, gastric cancer.