Research Article
Reexamining Povarov Reaction’s Scope and Limitation in the Generation of HCV-NS4A Peptidomimetics
Table 2
Results of Povarov reactions are shown in Scheme
2.
| Entry | Product | Catalyst | Product % |
| 1 | 4a | CAN | 59% | 2 | 4b | CAN | 18% | 3 | M-KSF | 62% | 4 | 4c | CAN | 80%, | 5 | M-KSF | 68% | 6 | 4d | CAN | 50% | 7 | M-KSF | 48% | 8 | 4e | CAN | ND | 9 | M-KSF | ND, 43% of [M+H]+ 202 | 10 | 4f | CAN | 32% product and 15% of [M+H]+ 202 | 11 | M-KSF | 22% product and 30% of [M+H]+ 202 | 12 | 4g | CAN | 80% | 13 | M-KSF | 20% | 14 | 4h | CAN | 50% | 15 | M-KSF | 48% | 16 | 4i | CAN | 40% | 17 | M-KSF | 52% | 18 | 4j | CAN | 38% | 19 | M-KSF | 11% | 20 | 4k | CAN | 32% | 21 | M-KSF | 25% | 22 | 4l | CAN | 31% | 23 | M-KSF | 52% | 24 | M-K10 | 46% | 25 | 4m | CAN | 35% | 26 | M-KSF | 6% | 27 | 4n | CAN | 43% | 28 | M-KSF | 32% |
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Abbreviations: CAN = ceric ammonium nitrate; M-KSF = Montmorillonite KSF; M-K10 = Montmorillonite K10.
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