Large Region of Homozygous (ROH) Identified in Indian Patients with Autosomal Recessive Limb-Girdle Muscular Dystrophy with p.Thr182Pro Variant in <i>SGCB</i> Gene

<div>ROH analysis. (a) Distribution of ROH (region of homozygosity) length (in kb) identified in case and control samples overlapping variant of interest (<i>SGCB</i> p.Thr182Pro). (b) Majority of cases contain a large ROH region (~1 Mb) overlapping variant of interest. (c) Length and frequency of ROH identified in the cases. The longest ROH extends up to 16.72 Mb which covers 2,929 markers and encompasses 50 protein-coding genes.</div>

Human Mutation

fig3

Figure 3

Figure 3: Large Region of Homozygous (ROH) Identified in Indian Patients with Autosomal Recessive Limb-Girdle Muscular Dystrophy with p.Thr182Pro Variant in <i>SGCB</i> Gene 

Figure 3 | Large Region of Homozygous (ROH) Identified in Indian Patients with Autosomal Recessive Limb-Girdle Muscular Dystrophy with p.Thr182Pro Variant in SGCB Gene 