Frequency and Functional Characterization of RUNX1 Germline Variants in Myeloid Neoplasms

Figure 4

(a) Schematic overview of study design. (b) Ratio of variant (variant of interest) and WT’ (synonymous variant) are plotted to estimate effect on proliferation. (c) Ratio of frameshift insertion and deletion to WT’. In (b) and (c), ratios have been normalized to the mean ratio at baseline (day 2). . Assay was performed as triplicates; we plotted individual values and deviations.

(a)

(b)

(c)