Quantitative Phenotype Morbidity Description of SATB2-Associated Syndrome

Table 1

Demographics and comparison of the SATB2-associated syndrome severity score overall and by age group and sex.

		Neurodevelopment		Systemic		Total
		Mean (SD)	value	Mean (SD)	value	Mean (SD)	value
Total	164	12.19 (4.38)		7.44 (2.87)		19.63 (6.17)
Age
3 to 5 years	29	12.24 (3.73)	0.07	6.86 (2.89)	0.25	19.10 (5.13)	0.07
6 to 10 years	70	11.21 (4.97)		7.21 (3.10)		18.43 (7.05)
11 to 17 years	41	13.20 (3.96)		8.12 (2.68)		21.32 (5.59)
≥18 years	24	13.25 (3.43)		7.66 (2.35)		20.92 (4.80)
Sex
Male	86	12.60 (4.31)	0.14	7.16 (2.75)	0.37	19.77 (6.12)	0.67
Female	78	11.73 (4.44)		7.75 (2.99)		19.49 (6.27)
Molecular^†
Null	93	12.45 (4.28)	0.72	7.71 (2.76)	0.33	20.16 (5.81)	0.44
Missense	45	11.82 (4.48)		6.93 (2.98)		18.76 (6.30)
Chromosomal	25	12.32 (4.18)		7.56 (3.00)		19.88 (6.63)

Abbreviation: SD: standard deviation. ^†One individual with an intronic variant not included.