The Association of Heterozygous p.R4810K of RNF213 and Long-Term Unfavorable Outcomes after Encephaloduroarteriosynangiosis in Chinese Pediatric Patients with Moyamoya Disease

Table 1

Summary of demographics, clinical presentation, and perioperative complication.

Baseline characteristics	No. of cases or value
Gender
Male	130 (50.19%)
Female	129 (49.81%)
Age at onset (years)	8 (6, 12)
Onset type
TIA	149 (57.53%)
Infarction	53 (20.46%)
Hematoma	12 (4.63%)
Headache	18 (6.95%)
Epilepsy	9 (3.47%)
Other	18 (6.95%)
Follow-up	7.73 (6.88, 8.52)
Onset → operation	7.4 (2.42, 25.28)
p.R4810K genotypes
AA	4 (1.54%)
GA	85 (32.82%)
GG	170 (65.64%)
Hyperlipidemia
No	236 (91.12%)
Yes	23 (8.88%)
Hyperhomocysteinemia
No	246 (94.98%)
Yes	13 (5.02%)
Family history
No	245 (94.59%)
Yes	14 (5.41%)
Laterality
Unilateral	8 (3.09%)
Bilateral	251 (96.91%)
Waiting infarction
No	172 (66.41%)
Yes	87 (33.59%)
Initial mRS
<2	238 (91.89%)
≥2	21 (8.11%)
Final mRS
<2	225 (86.87%)
≥2	34 (13.13%)
PCA involvement
No	188 (72.59%)
Unilateral	33 (12.74%)
Bilateral	38 (14.67%)
Suzuki stage
<IV	100 (38.61%)
≥IV	159 (61.39%)
Perioperative complications
No	252 (97.3%)
Infarction	5 (1.93%)
Hematoma	1 (0.39%)
Subdural effusion	1 (0.39%)
Hematoma during follow-up
No	258 (99.61%)
Yes	1 (0.39%)
Infarction during follow-up
No	251 (96.91%)
Yes	8 (3.09%)

Abbreviations: TIA: transient ischemic attack; PCA: posterior cerebral artery; mRS: modified Rankin scale.