The Association of Heterozygous p.R4810K of RNF213 and Long-Term Unfavorable Outcomes after Encephaloduroarteriosynangiosis in Chinese Pediatric Patients with Moyamoya Disease

Table 2

Comparison of baseline characteristics and outcomes between the unfavorable and favorable outcome groups.

Variables	Favorable outcome ()	Unfavorable outcome ()	value
Gender			0.833
Male	112 (50.45%)	16 (48.48%)
Female	110 (49.55%)	17 (51.52%)
Age at onset (years)	9 (6, 12)	6 (5, 9)	0.009
Onset with infarction			0.472
No	180 (81.08%)	25 (75.76%)
Yes	42 (18.92%)	8 (24.24%)
Onset with hematoma			<0.001
No	218 (98.2%)	25 (75.76%)
Yes	4 (1.8%)	8 (24.24%)
Onset operation	7.78 (2.6, 20.45)	9.07 (3.37, 20.93)	0.903
p.R4810K genotypes			0.692
GG	149 (67.12%)	21 (63.64%)
GA	73 (32.88%)	12 (36.36%)
Hyperlipidemia			1
No	202 (90.99%)	30 (90.91%)
Yes	20 (9.01%)	3 (9.09%)
Hyperhomocysteinemia			1
No	212 (95.5%)	31 (93.94%)
Yes	10 (4.5%)	2 (6.06%)
Family history			0.488
No	212 (95.5%)	30 (90.91%)
Yes	10 (4.5%)	3 (9.09%)
Laterality			1
Unilateral	7 (3.15%)	1 (3.03%)
Bilateral	215 (96.85%)	32 (96.97%)
Waiting infarction			<0.001
No	158 (71.17%)	11 (33.33%)
Yes	64 (28.83%)	22 (66.67%)
Initial mRS			<0.001
<2	211 (95.05%)	11 (33.33%)
≥2	11 (4.95%)	22 (66.67%)
PCA unilateral involvement			0.494
No	195 (87.84%)	27 (81.82%)
Yes	27 (12.16%)	6 (18.18%)
PCA bilateral involvement			0.151
No	193 (86.94%)	25 (75.76%)
Yes	29 (13.06%)	8 (24.24%)
Suzuki stage			0.327
<IV	87 (39.19%)	10 (30.3%)
≥IV	135 (60.81%)	23 (69.7%)
Perioperative infarction			0.007
No	221 (99.55%)	30 (90.91%)
Yes	1 (0.45%)	3 (9.09%)
Infarction during follow-up			0.117
No	217 (97.75%)	30 (90.91%)
Yes	5 (2.25%)	3 (9.09%)

Abbreviations: PCA: posterior cerebral artery; mRS: modified Rankin scale.