The Association of Heterozygous p.R4810K of RNF213 and Long-Term Unfavorable Outcomes after Encephaloduroarteriosynangiosis in Chinese Pediatric Patients with Moyamoya Disease

Table 3

Univariate and logistic regression analyses of risk factors for unfavorable outcome (final ).

Variables	OR [95% CI]	value
Gender (ref: male)	1.08 [0.52-2.25]	0.833
Age at onset	0.87 [0.79-0.97]	0.009
Onset with infarction	1.37 [0.58-3.25]	0.474
Onset with hematoma	17.44 [4.9-62.07]	<0.001
Onset → operation (ref: <2 mons)	0.44 [0.2-0.97]	0.042
p.R4810K GA (ref: GG)	1.17 [0.54-2.5]	0.692
Hyperlipidemia	1.01 [0.28-3.61]	0.988
Hyperhomocysteinemia	1.37 [0.29-6.54]	0.695
Family history	2.12 [0.55-8.14]	0.274
Laterality (ref: unilateral)	1.04 [0.12-8.75]	0.97
Waiting infarction	4.94 [2.26-10.77]	<0.001
Initial mRS (ref: <2)	38.36 [14.93-98.61]	<0.001
Unilateral PCA involvement	1.6 [0.61-4.24]	0.34
Bilateral PCA involvement	2.13 [0.88-5.17]	0.095
Suzuki stage (ref: <4)	1.48 [0.67-3.27]	0.329
Perioperative infarction	22.1 [2.23-219.35]	0.008
Infarction during follow-up	4.34 [0.99-19.09]	0.052

Abbreviations: CI: confidence interval; OR: odds ratio; PCA: posterior cerebral artery; mRS: modified Rankin scale.