Cholera Infection Risks and Cholera Vaccine Safety in Pregnancy
Table 4
Types, components, and characteristics of cholera vaccines.
Cholera vaccines
Components of cholera vaccines
Characteristics of cholera vaccines
Type I (Dukoral ®)
Killed whole-cell and recombinant cholera toxin B vaccine
First internationally licensed oral cholera vaccine
Type II (ORC-Vax™/mORC-Vax™, Shanchol™, Euvichol®, OraVacs)
Killed whole-cell only vaccines
Manufactured without the cholera toxin B to reduce cost and complexity of vaccine administration
Type III (CVD 103, Peru-15, Cuban 638, VA 1.4)
Live attenuated oral cholera vaccine
Mimics the natural cholera infection by inducing mucosal gut immune response
Type IV
Parenteral, killed whole-cell cholera vaccines
Administered for a short period of time due to their side effects in the recipients, limited protection for a short duration, and their inability to limit transmission of cholera