Stability-Indicating HPLC Determination of Trandolapril in Bulk Drug and Pharmaceutical Dosage Forms

Table 6

Stability data under different stressed conditions.

Stress conditions	% Trandolapril remained	Relative percentage of degraded products
Oxidative stress (30% H2O2)	40.9 (peak #2)	13.3 (peak #1), 3.38 (3), 10.05 (4), 26.65 (5), 3.35 (6), and 8.05 (7)
Acidic; (0.1 N HCl)	99.6 (peak #2)	0.2 (peak #1) and 0.2; (peak 3)
Alkaline; (0.1 N NaOH)	0.0	54.12 (peak #1), 2.22 (2), and 43.66 (3)
Ultraviolet light; (2 hours, 80 W)	100.0	0.0
Direct sunlight	100.0	0.0
Aqueous stability (after 21 days)	99.5 ± 0.1	0.0