An LC-MS/MS Method for Simultaneous Determination of the Toxic and Active Components of Cortex Periplocae in Rat Plasma and Application to a Pharmacokinetic Study

Table 3

Pharmacokinetic parameters of the analytes (n = 6, mean ± SD).

parameters	scopoletin	periplocin	periplogenin	periplocymarin
(h)	0.10 ± 0.03	0.31 ± 0.16	5.78 ± 3.56	5.49 ± 4.34
Cmax (ng/mL)	177.8 ± 133.85	91.37 ± 52.95	14.53 ± 7.75	125.96 ± 96.42
AUC(0-tn) (ng h/mL)	103.00 ± 76.36	82.98 ± 58.62	206.57 ± 130.58	1689.73 ± 1174.92
AUC(0-∞) (ng h/mL)	205.81 ± 152.57	105.05 ± 70.88	446.29 ± 174.38	2258.69 ± 1284.45
(h)	0.19 ± 0.08	1.08 ± 0.98	22.91 ± 17.30	30.18 ± 11.83
MRT(0-tn) (h)	11.81 ± 6.60	1.21 ± 1.11	19.07 ± 3.64	17.15 ± 2.48