Simultaneous Determination of 13 Constituents of Radix Polygoni Multiflori in Rat Plasma and Its Application in a Pharmacokinetic Study

Table 3

Pharmacokinetic parameters of 10 analytes after oral administration of RPM extract (n = 6).

Compound	Cmax (ng/ml)	Tmax (h)	t1/2 (h)	AUC0–t (ng·h/ml)	AUC0–∞ (ng·h/ml)	MRT0–∞ (h)
Chrysophanol	1.90 ± 0.56	2.22 ± 1.76	3.18 ± 0.62	4.28 ± 1.64	10.3 ± 1.87	6.76 ± 2.06
Emodin	175 ± 33.8	0.19 ± 0.09	8.37 ± 4.17	686 ± 187	801 ± 233	11.8 ± 5.27
Aloe-emodin	11.3 ± 3.10	0.22 ± 0.07	3.44 ± 1.40	7.28 ± 3.25	8.46 ± 3.44	3.17 ± 1.54
Rhein	1.06 ± 0.24	0.46 ± 0.10	1.18 ± 0.39	1.11 ± 0.63	2.31 ± 0.51	1.83 ± 0.56
Citreorosein	149 ± 147	0.19 ± 0.09	3.97 ± 1.31	131 ± 96.9	134 ± 96.4	5.32 ± 1.85
Questinol	1.20 ± 0.20	4.38 ± 4.03	8.90 ± 2.70	14.2 ± 2.06	17.3 ± 2.84	13.6 ± 4.21
TSG	1743 ± 401	0.33 ± 0.13	5.98 ± 2.62	1811 ± 554	1871 ± 581	3.66 ± 0.97
TG	18.7 ± 4.06	0.11 ± 0.07	2.00 ± 0.63	21.2 ± 7.38	21.7 ± 7.48	2.10 ± 0.24
EG	101 ± 47.4	0.29 ± 0.10	3.92 ± 2.50	82.5 ± 32.1	83.7 ± 32.3	2.88 ± 1.41
PG	18.8 ± 4.85	0.26 ± 0.13	6.13 ± 1.06	79.5 ± 8.95	84.1 ± 8.31	8.58 ± 1.72