Comprehensive Screening and Identification of Phillyrin Metabolites in Rats Based on UHPLC-Q-Exactive Mass Spectrometry Combined with Multi-Channel Data Mining

Figure 4

High-resolution extracted ion chromatograms of phillyrin metabolites (A-E) for negative ion mode and (F-J) for positive ion mode): (a) m/z 339.2035, 417.1179, 451.1057, 507.2225, and 579.2072; (b) m/z 261.1146, 271.0602, 315.0865, 437.0901, 453.0850, and 519.1498; (c) m/z 271.1329, 357.1332, 377.0689, 533.1652, and 547.1809; (d) m/z 329.1021, 333.1327, 345.0968, 359.1490, 375.1074, and 409.0588; (e) m/z 331.1177, 343.1177, and 347.1126; (f) m/z 298.0962, 305.1772, 315.1227, 341.1384, 377.1953, and 393.1543; (g) m/z 231.1404, 331.0811, 355.1541, and 492.1687; (h) m/z 273.1486, 285.0759, and 557.1993; (i) m/z 317.0657, 331.1178, 333.1332, and 371.1489; and (j) m/z 281.1173, 295.0964, 313.1070, 317.1384, 357.1332, 373.1281, and 373.1646.

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