Rapid Determination of Pemetrexed Concentration and Distribution in Human Breast Cancer Cells (McF-7) Based on UHPLC-MS/MS

<table class="table-group" id="tab4"><tr><td><table class="table"><tr><td class="thead-hr" colspan="6"><hr/></td></tr><tr class="thead"><td class="align_left" rowspan="2">Analyte</td><td class="align_center" rowspan="2">Spiked concentration (ng/mL)</td><td class="align_center" colspan="2">Recovery</td><td class="align_center" colspan="2">Matrix effect</td></tr><tr class="thead"><td class="align_center">Mean (%) ± SD</td><td class="align_center">RSD (%)</td><td class="align_center">Mean (%) ± SD</td><td class="align_center">RSD (%)</td></tr><tr><td class="thead-hr" colspan="6"><hr/></td></tr><tr><td class="align_left" rowspan="2">Pemetrexed</td><td class="align_center">5</td><td class="align_center">63.55 ± 0.12</td><td class="align_center">9.25</td><td class="align_center">98.10 ± 0.05</td><td class="align_center">5.32</td></tr><tr><td class="align_center">100</td><td class="align_center">47.50 ± 0.01</td><td class="align_center">1.70</td><td class="align_center">100.62 ± 0.01</td><td class="align_center">1.31</td></tr><tr class="table-tr"><td colspan="6"><hr class="tbody-hr"/></td></tr></table></td></tr></table>

<div>The extraction recovery and matrix effect results of pemetrexed.</div>

International Journal of Analytical Chemistry

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Table 4

Table 4: Rapid Determination of Pemetrexed Concentration and Distribution in Human Breast Cancer Cells (McF-7) Based on UHPLC-MS/MS 