Research Article
Rapid Determination of Pemetrexed Concentration and Distribution in Human Breast Cancer Cells (McF-7) Based on UHPLC-MS/MS
Table 5
Results of stability investigation of pemetrexed (n = 6).
| | Analyte | Nominal concentration (ng/mL) | Freeze-thaw stability | 24 h in autosampler | Long-term stability (3 months) | | Measured concentration (ng/mL) | Accuracy (RE%) | Measured concentration (ng/mL) | Accuracy (RE%) | Measured concentration (ng/mL) | Accuracy (RE%) |
| | Pemetrexed | 5 | 4.52 | 90.40 | 4.84 | 96.80 | 4.47 | 89.40 | | 100 | 88.29 | 88.29 | 89.48 | 89.48 | 87.35 | 87.35 |
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