Simultaneous Quantification of Aspirin, Its Metabolite Salicylic Acid, and Salvianolic Acid B in Human Plasma Using UPLC-MS/MS

Table 6

Measured concentrations of Sal B, ASA, and SA in patients.

Collection time		Sal B conc. (ng/mL)		ASA conc. (ng/mL)		SA conc. (ng/mL)
		SV group	A + S group	AP group	A + S group	AP group	A + S group
8th day	Before	<LLOQ	8.27	<LLOQ	<LLOQ	99.8	22.8
9th day	Before	<LLOQ	7.73	<LLOQ	<LLOQ	76.6	24.9
10th day	Before	<LLOQ	12.3	<LLOQ	<LLOQ	69.7	18.5
	5 min	NA	NA	<LLOQ	NA	63.1	NA
	15 min	2078	1059	<LLOQ	<LLOQ	50.3	18.0
	30 min	1274	653	<LLOQ	<LLOQ	51.8	17.3
	45 min	720	436	<LLOQ	<LLOQ	48.6	15.5
	1 h	471	246	<LLOQ	<LLOQ	46.2	18.5
	2 h	211	128	<LLOQ	12.4	27.2	375
	4 h	64.5	43.3	270	239	1725	2157
	8 h	34.0	24.9	22.9	79.2	2229	1740
	12 h	15.9	16.3	104	6.05	1191	640
	24 h	14.9	9.96	<LLOQ	<LLOQ	84.7	57.2

NA represents that the administration group was not collected sample at 5 min after administration.