Simultaneous Quantification of Aspirin, Its Metabolite Salicylic Acid, and Salvianolic Acid B in Human Plasma Using UPLC-MS/MS

Table 7

Mean of pharmacokinetic parameters of Sal B in the SV group and A + S group and SA in AP group and A + S group (mean ± SD%).

Parameter	Sal B		SA
	SV group (n = 5)	A + S group (n = 5)	AP group (n = 6)	A + S group (n = 5)
Tmax (h)	1.6 ± 0.1	1.6 ± 0.1	7.3 ± 3.0	5.6 ± 2.2
Cmax (μg/mL)	2.3 ± 1.8	1.1 ± 0.5	3.3 ± 1.1	2.8 ± 1.0
T1/2 (h)	4.4 ± 1.5	7.3 ± 5.3	2.6 ± 0.8	2.8 ± 0.8
AUC0-t (h × μg/mL)	3.5 ± 1.9	1.9 ± 0.8	24 ± 7.5	19 ± 8.9
AUC0-∞ (h × μg/mL)	3.6 ± 2.0	2.1 ± 0.9	24 ± 7.3	20 ± 9.0

T_max: time point of maximum plasma concentration; C_max: maximum plasma concentration; T_1/2: half-life of drug elimination during the terminal phase; AUC_0-t: area under the plasma concentration-time curve from zero hours to last time point; and AUC_0-∞: area under the plasma concentration-time curve from zero hours to infinity.