Analytical Quality by Design Approach of Reverse-Phase High-Performance Liquid Chromatography of Atorvastatin: Method Development, Optimization, Validation, and the Stability-Indicated Method

Figure 2

(a) Effect of acetonitrile, flow rate, and wavelength on the area. (b) Effect of acetonitrile, flow rate, and wavelength on the retention time. (c) Effect of acetonitrile, flow rate, and wavelength on the tailing factor.

(a)

(b)

(c)