Determination and Pharmacokinetics of Omeprazole Enantiomers in Human Plasma and Oral Fluid Utilizing Microextraction by Packed Sorbent and Liquid Chromatography-Tandem Mass Spectrometry

Figure 3

Effect of mobile phase composition on the separation of OME enantiomers: (a) hexane + isopropanol (80 : 20) as mobile phase, (b) hexane + ethanol (80 : 20), and (c) hexane + ethanol + NH₃OH (70 : 30 : 0.2 v/v).

(a)

(b)

(c)