Simultaneous Determination of Lamotrigine, Oxcarbazepine, Lacosamide, and Topiramate in Rat Plasma by Ultra-Performance Liquid Chromatography-Tandem Mass Spectrometry

Figure 3

UPLC-MS/MS chromatograms of lamotrigine, oxcarbazepine, lacosamide, topiramate, and internal standard in rat plasma samples. Blank plasma sample (a); blank plasma spiked with lamotrigine and oxcarbazepine, lacosamide, topiramate, and internal standard (b); a rat plasma sample after the administration of the lamotrigine, oxcarbazepine, lacosamide, and topiramate (c).

(a)

(b)

(c)