Research Article

Simultaneous Determination of Lamotrigine, Oxcarbazepine, Lacosamide, and Topiramate in Rat Plasma by Ultra-Performance Liquid Chromatography-Tandem Mass Spectrometry

Table 1

The equations of the standard curve of lamotrigine, oxcarbazepine, lacosamide, and topiramate in rat plasma.

CompoundEquationsR2Range (ng/mL)LLOQ (ng/mL)

Lamotriginey = 0.0005x + 0.00080.99875–50005
Oxcarbazepiney = 0.0062x + 0.00550.99975–50005
Lacosamidey = 0.0784x + 0.06910.99815–50005
Topiramatey = 0.00004x−0.000030.99955–50005