Simultaneous Determination of Lamotrigine, Oxcarbazepine, Lacosamide, and Topiramate in Rat Plasma by Ultra-Performance Liquid Chromatography-Tandem Mass Spectrometry

Table 2

Accuracy, precision, matrix effect, and recovery of lamotrigine, oxcarbazepine, lacosamide, and topiramate in rat plasma.

Compound	Concentration (ng/mL)	Precision (RSD %)		Accuracy (%)		Matrix effect (%)	Recovery (%)
		Intraday	Interday	Intraday	Interday
Lamotrigine	5	14.6	14.9	92.7	107.2	96.9	99.0
	10	8.3	12.1	101.7	101.2	95.6	94.0
	900	7.2	4.3	96.3	98.5	96.2	91.5
	4500	5.2	6.1	106.3	98.8	91.7	97.6
	5	11.0	13.1	107.6	93.4	103.2	96.0
Oxcarbazepine	10	6.1	10.7	99.4	105.8	99.9	93.8
	900	13.8	7.9	103.1	106.2	96.2	94.3
	4500	4.1	8.1	102.0	98.4	97.7	93.5
	5	9.1	8.8	93.6	108.2	101.8	92.2
Lacosamide	10	3.1	6.1	103.6	97.5	104.6	94.8
	900	5.6	3.4	97.7	104.2	98.3	98.4
	4500	4.8	5.8	99.1	102.9	98.3	96.7
	5	11.0	13.7	93.6	108.0	89.4	90.2
Topiramate	10	3.4	9.4	103.3	103.1	92.4	93.6
	900	9.1	5.5	97.7	98.6	95.8	88.8
	4500	3.0	8.0	95.3	96.1	99.0	90.4