International Journal of Analytical Chemistry

Research Article

Simultaneous Determination of Lamotrigine, Oxcarbazepine, Lacosamide, and Topiramate in Rat Plasma by Ultra-Performance Liquid Chromatography-Tandem Mass Spectrometry

Table 4

Pharmacokinetic parameters of lamotrigine, oxcarbazepine, lacosamide, and topiramate after oral administration in rats.
ParametersUnitLamotrigineOxcarbazepineLacosamideTopiramate
AUC(0-t)ng/mLh97824.5 ± 8269.94989.3 ± 1047.69270.3 ± 3231.716571.0 ± 7910.9
AUC(0-∞)ng/mLh154786.8 ± 86468.66364.0 ± 2161.010586.9 ± 4015.817329.1 ± 8451.5
MRT(0-t)h9.4 ± 0.73.6 ± 0.33.6 ± 0.53.0 ± 0.6
MRT(0-∞)h19.8 ± 8.45.1 ± 1.93.6 ± 0.43.1 ± 0.6
t1/2zh14.9 ± 11.44.8 ± 2.03.3 ± 2.82.5 ± 1.2
Tmaxh2.8 ± 1.50.5 ± 0.10.8 ± 0.50.6 ± 0.3
CLzL/h/kg0.04 ± 0.010.9 ± 0.20.5 ± 0.20.4 ± 0.2
VzL/kg0.7 ± 0.15.7 ± 2.92.2 ± 1.31.5 ± 1.7
Cmaxng/mL6776.1 ± 916.21713.1 ± 361.32258.2 ± 686.65203.4 ± 1650.8