Quality-by-Design Principles Applied to the Establishment of a Pharmaceutical Quality Control Laboratory in a Resource-Limited Setting: The Lab Water

Table 4

Overall analytical quality of different water grades in JuLaDQ using different parameters.

#	Water type	Typical chromatogram	Total peak area (mAU)		UV-absorbance (AU)		Conductivity (μS/cm) (resistivity in MΩ.cm)	Water R ph. Int. Compliance
			210 nm	254 nm	210 nm	254 nm
1	Tap water		92435	8520	0.623	0.111	503 (0.002)	Did not comply
2	Distilled water before cleaning		88206	7199	0.399	0.107	0.53 (1.9)	NA
3	Distilled water after cleaning		43384	3551	0.317	0.097	0.52 (1.9)	Complies
4	Ultrapure water		722	59	0.098	0.054	0.055 (18.2)	Complies

NA: not applicable.