Determination of Senegenin and Tenuifolin in Mouse Blood by Ultra-High Performance Liquid Chromatography-Tandem Mass Spectrometry and Their Pharmacokinetics

Table 1

Accuracy, precision, matrix effect, and recovery of senegenin and tenuifolin in mouse blood.

Compound	Concentration (ng/mL)	Accuracy (%)		Precision (RSD%)		Matrix effect (%)	Recovery (%)
		Intraday	Interday	Intraday	Interday
Senegenin	5	108.8	91.3	11.1	11.5	87.7	94.2
	10	104.6	102.0	10.8	6.6	87.3	94.9
	450	102.8	96.4	6.7	11.3	89.0	90.1
	3500	96.1	103.7	6.7	10.9	93.4	93.1
Tenuifolin	5	109.5	87.0	11.7	13.8	88.4	97.7
	10	96.7	107.4	5.4	12.4	93.4	95.2
	450	108.0	89.1	9.8	9.0	86.1	88.9
	3500	93.5	106.3	10.5	12.0	88.4	96.4