Determination of Senegenin and Tenuifolin in Mouse Blood by Ultra-High Performance Liquid Chromatography-Tandem Mass Spectrometry and Their Pharmacokinetics

Table 3

The main pharmacokinetic parameters of senegenin and tenuifolin after intravenous (iv) and oral (po) administration in mice.

Compound	Group	AUC(0-t) (ng/mLh)	AUC(0-∞) (ng/mLh)	t1/2z (h)	CLz/F (L/h/kg)	Vz/F (L/kg)	Cmax (ng/mL)
Senegenin	PO, 60 mg/kg	434.2 ± 67.8	454.7 ± 66.0	2.6 ± 0.6	134.3 ± 21.8	503.0 ± 152.0	119.7 ± 30.8
	IV, 5 mg/kg	994.3 ± 116.0	998.0 ± 116.5	1.6 ± 0.4	5.1 ± 0.7	12.2 ± 4.1	1910.6 ± 279.2
Tenuifolin	PO, 60 mg/kg	170.8 ± 20.8	176.1 ± 21.2	1.1 ± 0.2	343.8 ± 38.7	554.7 ± 23.3	98.3 ± 19.0
	IV, 5 mg/kg	845.4 ± 171.2	849.4 ± 172.6	0.8 ± 0.2	6.1 ± 1.4	7.2 ± 2.2	1497.3 ± 351.2