Review on Characterization, Properties, and Analytical Methods of Cefepime

Table 2

Micellar electrokinetic chromatographic methods for determination of CP.

Technique	Column (C)	Mobile phase or eluent	Conditions	Matrices	Reference
MEKC	Uncoated FSC of 50 μm	6 mM Na2B4O7, 10 mM Na2HPO4, 75 mM SDS pH 9.1	257, V of 15 kV	Human serum and plasma	[50]
MEKC	Uncoated FSC of 40.2 cm × 50 μm id	Tris with SDS : MeOH	214, V of 15 kV	Plasma and cerebrospinal fluid	[51]
MEKC	Uncoated FSC of 31.2 cm (21 cm × 675 mm ID)	10 mM tris buffer pH 8.0 + 150 mM SDS and 20 mM tris buffer pH 9.0 + 200 mM SDS	254, V was 8 kV	Plasma and cerebrospinal fluid	[52]
MEKC	Bare FSC of 50 µm, 5 mmol with length 56 cm	Imidazole buffer pH 5.1	240, V of 25 kV	NMP in CP for injection	[53]
MEKC	Uncoated FSC length 31.2 cm	Tris buffer + SDS as an electrolyte solution	214, V of 15 kV	Commercial injections	[54]
MEKC + indirect UV	MEKC [A 50 lm i.d 64.5 cm (56 cm detection length) bare FSC]; IC [Gel IC-Cation-SW C (4.6 50 mm, 5 lm) supported by a water’s cation GC (4.6·50 mm, 10 lm)]	MEKC (10 mM creatinine pH 3.8); IC (ACN: 0.01 mM nitric acid) (1 : 100)	225; MEKC (V of 30 kV); IC (1)	NMP in CP for injection	[55]
CZE	FSC (48.6 cm × 50 µm i.d.) with 40.2 cm as a detection length 40.2 cm)	15 mm sodium borate buffer pH 9.3	215, V was 20 kV	Pharmaceutical formulations and; human plasma	[56]

(ml/min); (nm).