Formulation and Development of a Water-in-Oil Emulsion-Based Luliconazole Cream: In Vitro Characterization and Analytical Method Validation by RP-HPLC

Table 1

Formulation of w/o emulsion-based LCZ cream.

S. no.	Materials (gm/tube)	F1	F2	F3	F4	F5
1	Luliconazole	0.100	0.100	0.100	0.100	0.100
2	Cetostearyl alcohol	1.254	1.192	1.208	1.224	1.214
3	Liquid paraffin (light)	0.450	0.470	0.440	0.480	0.500
4	Cetomacrogol 1000	0.3	—	—	—	—
5	White soft paraffin	—	0.270	0.272	0.275	0.275
6	Sodium hydroxide	—	0.250	—	—	—
7	Benzoic acid	—	—	0.150	—	—
8	Tween-80	—	—	—	0.25	0.100
9	Sodium lauryl sulfate	0.100	0.100	0.100	0.100	0.100
10	Sodium metabisulfite	0.010	0.010	0.010	0.010	0.010
11	Propylene glycol	1.400	1.400	1.400	1.400	1.400
12	Purified water	6.386	6.208	6.320	6.161	6.301
Total weight (gm)	10.000	10.000	10.000	10.000	10.000	10.000