Research Article
Formulation and Development of a Water-in-Oil Emulsion-Based Luliconazole Cream: In Vitro Characterization and Analytical Method Validation by RP-HPLC
Table 10
Stability study parameters for LCZ.
| | Duration | Temp. (°C) | Humidity (%) | Assaya (%) | Color change | pHa | Creamy consistency |
| | 1 day | 25 | NA | 101.29 ± 0.25 | − | 4.75 ± 0.21 | + | | 40 | 75 | 102.44 ± 0.31 | − | 4.79 ± 0.13 | + |
| | 1 month | 25 | NA | 101.14 ± 0.18 | − | 4.91 ± 0.17 | + | | 40 | 75 | 101.55 ± 0.15 | − | 4.87 ± 0.12 | + |
| | 3 months | 25 | NA | 102.43 ± 0.23 | − | 4.85 ± 0.10 | + | | 40 | 75 | 100.56 ± 0.13 | − | 4.92 ± 0.15 | + |
| | 6 months | 25 | NA | 101.99 ± 0.27 | − | 4.77 ± 0.16 | + | | 40 | 75 | 99.89 ± 0.08 | − | 4.82 ± 0.11 | + |
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aValues are expressed as mean ± SD (n = 3); +: presence; −: absence; NA : not applicable.
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