Pharmacokinetic Difference of Six Active Constituents of Huangqi Liuyi Decoction between Control and Diabetic Nephropathy Mouse Models

Table 10

The pharmacokinetic parameters of ononin after HQD administration ( ± SD, n = 8).

Pharmacokinetic parameter	Unit	Ononin
		Control group	Model group
T1/2	h	1.31 ± 0.02	1.63 ± 0.83
Tmax	h	1.38 ± 0.25	1.25 ± 0.29
Cmax	ng/mL	351.6 ± 63.44	677.4 ± 157.9
AUC(0–t)	ngh/mL	576.0 ± 43.31	817.0 ± 93.25
AUC(0–∞)	ngh/mL	596.4 ± 44.22	865.9 ± 106.9
VZ/F	mL/kg	4434.7 ± 357.0	3739 ± 1618
CLZ/F	mL/h/kg	2343 ± 171.8	1633 ± 226.9
MRT(0–t)	h	1.80 ± 0.21	1.67 ± 0.14
MRT(0–∞)	h	2.04 ± 0.27	2.14 ± 0.32

ps: vs. control group, ^∗P < 0.05, ^∗∗P < 0.01.