Pharmacokinetic Difference of Six Active Constituents of Huangqi Liuyi Decoction between Control and Diabetic Nephropathy Mouse Models

Table 11

The pharmacokinetic parameters of formononetin after HQD administration ( ± SD, n = 8).

Pharmacokinetic parameter	Unit	Formononetin
		Control group	Model group
T1/2	h	3.17 ± 0.47	4.71 ± 1.17
Tmax	h	0.63 ± 0.25	0.75 ± 0.29
Cmax	ng/mL	191.1 ± 69.46	354.9 ± 74.35
AUC(0–t)	ngh/mL	429.4 ± 24.92	645.03 ± 105.8
AUC(0–∞)	ngh/mL	460.1 ± 32.3	730.61 ± 88.31
VZ/F	mL/kg	4791.9 ± 346.9	4569 ± 1498
CLZ/F	mL/h/kg	1047 ± 76.97	664.3 ± 80.3
MRT(0–t)	h	2.92 ± 0.22	3.04 ± 0.28
MRT(0–∞)	h	3.83 ± 0.39	4.96 ± 0.96

ps: vs. control group, ^∗P < 0.05, ^∗∗P < 0.01.