Research Article
Pharmacokinetic Difference of Six Active Constituents of Huangqi Liuyi Decoction between Control and Diabetic Nephropathy Mouse Models
Table 3
Intra- and interday precision and accuracy of six analytes in mouse plasma (
± SD,
n = 6).
| | Analyte | Concertation of analyte (ng/mL) | Mean ± SD (ng/mL) | Accuracy (%) | Interday precision RSD (%) | Intraday precision RSD (%) |
| | Astragaloside IV | 16.02 | 15.01 ± 0.66 | 93.68 ± 6.71 | 4.42 | 8.47 | | 801 | 813.9 ± 74.06 | 101.6 ± 1.99 | 9.10 | 6.56 | | 1602 | 1522 ± 107.33 | 95.03 ± 7.20 | 7.05 | 7.08 |
| | Calycosin-7-O-β-D-glucoside | 15.15 | 15.59 ± 1.55 | 102.9 ± 5.23 | 9.94 | 8.92 | | 75.75 | 67.65 ± 5.51 | 89.31 ± 7.56 | 8.14 | 5.39 | | 151.5 | 157.8 ± 5.67 | 104.2 ± 7.83 | 3.59 | 6.70 |
| | Calycosin-glucuronide | 10.38 | 8.57 ± 0.48 | 82.57 ± 1.91 | 2.31 | 5.57 | | 519 | 492.9 ± 23.56 | 94.98 ± 9.15 | 4.78 | 6.10 | | 1038 | 927.5 ± 81.62 | 89.35 ± 7.03 | 8.80 | 5.27 |
| | Formononetin | 5.23 | 5.02 ± 0.44 | 95.97 ± 8.32 | 8.67 | 6.41 | | 261.5 | 266.6 ± 19.86 | 101.9 ± 7.59 | 7.45 | 7.59 | | 313.8 | 307.4 ± 41.02 | 97.83 ± 10.18 | 13.35 | 7.10 |
| | Ononin | 10.41 | 9.35 ± 0.77 | 92.24 ± 5.93 | 8.22 | 7.61 | | 507 | 445.8 ± 32.63 | 87.93 ± 5.11 | 7.32 | 10.16 | | 1014 | 1051 ± 60.94 | 103.6 ± 6.96 | 5.80 | 4.40 |
| | Glycyrrhizic acid | 12.73 | 11.89 ± 1.3 | 93.40 ± 10.24 | 10.96 | 3.22 | | 1273 | 1046 ± 62.99 | 82.23 ± 1.34 | 1.62 | 5.28 | | 2545 | 2525 ± 142.15 | 99.21 ± 3.96 | 5.63 | 4.38 |
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